摘要英文

附件5

中国医院协会医院科技创新奖

推荐项目摘要

（中英文）

Project Name: The Study of Heat Shock Proteins 70 in Healthy People and the Old Patients With Cerebral Infarction

The first person to complete the project: Xingfang Jin

Unit name: Kunming Yanan Hospital

The time of these researches: May 1^st 2001 to December 16^th , 2007

Sources of funding in these researches:

Abstract：（800 to 1000 words）

Background

Heat shock protein 70 (HSP70) is a class of proteins induced by stress in organisms. In recent years, people have recognized that HSP70 has played an important role in protecting proteins in both physiology and pathology states. However, most of these researches about HSP70 at home and abroad are animal experiments and lack of large sample studies in healthy people. The correlation researches between HSP70 expression level in serum or lymphocytes and age, gender are absent, which between HSP70 expression in patients with cerebral infarction (CI^（2）) and severity are absent too. Therefore, the correlation researches between HSP70 expression level in serum or lymphocytes and age are carryed out by us, which could get the mutative regularity of HSP70 levels with age. At the same time, the correlation researches between HSP70 expression level in the old patients with cerebral infarction and neurological function defect are carryed out by us too, which could analyze the protecting role of HSP70 in cerebral ischemia patients. According to the study of HSP70 in Healthy People and the old patients with cerebral infarction, we will obtain the role of HSP70 in human both physiology and pathology states.

Method

The study enrolled 429 healthy people and 92 CI patients. In healthy group, Western blot method was used to determine the basal expression level of HS70 in serum of 327 healthy male and lymphocytes of 102 healthy adults. The relationship between HSP70 expression level with age and gender were analyzed. According to “The Scoring Criteria of Neurological Function Defect in Patients with Stroke”, the patients in CI group were divided into 3 subgroups: mild, moderate and severe. At the 1^st, 15^th, 30^th days after the onset of CI, HSP70 level in lymphocytes were determined respectively and the neurological deficit scores were counted simultaneously. Then the correlation between them was analyzed.

Inventions, innovations and the main contribution

(1) In human, HSP70 has played an important role both in physiology and pathology states. (2)In healthy people, the HSP70 expression level both in serum and lymphocytes is related to aging. We test the basic expression level of HSP70 and make it as a reference index to estimate the tolerant ability of these people in diseased condition and harmful environment. (3) The level of HSP70 in cerebral infarction patients is dynamically and closely related to different state of illness. In different time after cerebral infarction, HSP70 expression level could be tested as a biological marker to estimate patients’ condition and prognosis.

Application situation

1. We have published six articles in authoritative medical journal at home and aboard, two of which in “THE AMERICAN JOURNAL OF MEDCINE” and “CELL STRESS & CHAPERONES” are SCI included articles. The Impact Factor (IF) is 4.907 and 3.097 respectively. There are 33 articles cited in world famous medical journals, such as “THE NEW ENGLAND JOURNAL OF MEDICINE”,”EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY” and so on. Many published articles of these researches are referenced by readers.

2. The research results are popularized in a number of hospitals, such as neurological department and geriatric department in our hospital, Chenggong Hospital, Songming Hospital, Dongfeng Hospital, Taihe Hospital and the People’s Hospital of Shiyan, and they produced good social and indirect economic benefits.

Social and economic benefits

We popularized and applyed the research results in a number of hospitals. The research results could guide treatment, shorten the course of disease, reduce mortality and morbidity, improve quality of life, strengthen the doctor-patient communication, play a positive role, and produce good social and indirect economic benefits which directly saved more than 120 million yuan of the medical costs.

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